LETTERATURA SCIENTIFICA

A partire dal primo trapianto di sangue del cordone ombelicale nel 1988, lo sviluppo della ricerca che riguarda le cellule staminali cordonali è stato accompagnato da innumerevoli pubblicazioni, apparse sulle più prestigiose riviste mediche e scientifiche.
Quella che segue è una selezione degli studi più recenti, ordinati in base alla patologia cui si riferiscono e preceduti dalla citazione delle pubblicazioni considerate come “pietre miliari” della ricerca in questo settore.

 

In generale sul trapianto del sangue del cordone ombelicale

  1. Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells

    Hal E. Broxmeyer, Gordon W. Douglas, Giao Hangoc, Scott Cooper, Judith Bard, Denis English, Margaret Arny, Lewis Thomas, and Edward A. Boyse

    Medical Sciences, Vol. 86, pp. 3828-3832, May 1989

  2. Hematopoietic reconstitution in a patient with Fanconi‘s anemia by means of umbilical-cord blood from an HLA-identical sibling

    Eliane Gluckman, Hal E. Broxmeyer, Arleen D. Auerbach, Henry S. Friedman, Gordon W. Douglas, Agnes Devergie, Helene Esperou, Dominique Thierry, Gerard Socie, Pierre Lehn, Scott Cooper, Denis English, Joanne Kurtzberg, Judith Bard, and Edward A. Boyse

    Cellular Therapy and Transplantation (CTT), Vol. 2, No. 7 doi: 10.3205/ctt-2010-en-000079.01

  3. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells

    Anthony E. Boitano, Jian Wang, Russell Romeo, Laure C. Bouchez, Albert E. Parker, Sue E. Sutton, John R. Walker, Colin A. Flaveny, Gary H. Perdew, Michael S. Denison, Peter G. Schultz,and Michael P. Cooke

    Science, 2010 September 10; 329(5997): 1345–1348. doi:10.1126/science.1191536

  4. Hematopoietic stem/progenitor cells, generation of induced pluripotent stem cells, and isolation of endothelial progenitors from 21- to 23.5-year cryopreserved cord blood

    Hal E. Broxmeyer, Man-Ryul Lee, Giao Hangoc, Scott Cooper, Nutan Prasain, Young-June Kim, Coleen Mallett, Zhaohui Ye, Scott Witting, Kenneth Cornetta, Linzhao Cheng, and Mervin C. Yoder

    Blood, 5 May 2011, Volume 117, Number 18

  5. Family-directed umbilical cord blood banking

    Eliane Gluckman, Annalisa Ruggeri, Vanderson Rocha, Etienne Baudoux, Michael Boo, Joanne Kurtzberg, Kathy Welte, Cristina Navarrete, and Suzanna M. van Walraven for Eurocord, Netcord, World Marrow Donor Association and National Marrow Donor Program.

    Haematologica 2011; 96 (11)

  6. Double unit grafts successfully extend the application of umbilical cord blood transplantation in adults with acute leukemia

    Andromachi Scaradavou, Claudio G. Brunstein, Mary Eapen, Jennifer Le-Rademacher, Juliet N. Barker, Nelson Chao, Corey Cutler, Colleen Delaney, Fangyu Kan, Luis Isola, Chatchada Karanes, Mary J. Laughlin, John E. Wagner, and Elizabeth J. Shpall

    Blood, 31 January 2013, Volume 121, Number 5

  7. Cord-Blood Engraftment with Ex Vivo Mesenchymal-Cell Coculture

    Marcos de Lima, Ian McNiece, Simon N. Robinson, Mark Munsell, Mary Eapen, Mary Horowitz, Amin Alousi, , Rima Saliba, John D. McMannis, Indreshpal Kaur, Partow Kebriaei, Simrit Parmar, Uday Popat, Chitra Hosing, Richard Champlin, Catherine Bollard, Jeffrey J. Molldrem, Roy B. Jones, Yago Nieto, Borje S. Andersson, Nina Shah, Betul Oran, Laurence J.N. Cooper, Laura Worth, Muzaffar H. Qazilbash, Martin Korbling, Gabriela Rondon, Stefan Ciurea, Doyle Bosque, Ila Maewal, Paul J. Simmons, and Elizabeth J. Shpall

    The New England Journal of Medicine, 2012;367:2305-15.
    Doi: 10.1056/NEJMoa1207285

  8. Cord Blood Banking and Transplantation: Advances and Controversies

    Mervin C Yoder

    Current Opinion in Pediatrics, 2013

  9. Umbilical cord blood transplantation: the first 25 years and beyond

    Karen K. Ballen, Eliane Gluckman and Hal E. Broxmeyer

    Blood, 2013 122: 491-498
    Doi:10.1182/blood-2013-02-453175

Patologie ematologiche

  1. A novel mutation in Wiskott–Aldrich syndrome and successfully treated with umbilical cord blood transplantation

    Xiaoyu Zhu, Baolin Tang, Changcheng Zheng, Huilan Liu, Kaidi Song, Zimin Sun

    Blood Cells Mol. Diseases (2014)

  2. Transplantation in patients with SCID: mismatched related stem cells or unrelated cord blood?

    Juliana F. Fernandes, Vanderson Rocha, Myriam Labopin, Benedicte Neven, Despina Moshous, Andrew R. Gennery, Wilhelm Friedrich, Fulvio Porta, Cristina Diaz de Heredia, Donna Wall, Yves Bertrand, Paul Veys, Mary Slatter, Ansgar Schulz, Ka Wah Chan, Michael Grimley, Mouhab Ayas, Tayfun Gungor, Wolfram Ebell, Carmem Bonfim, Krzysztof Kalwak, Pierre Taupin, Stéphane Blanche, H. Bobby Gaspar, Paul Landais, Alain Fischer, Eliane Gluckman, and Marina Cavazzana-Calvo, on behalf of Eurocord and the Inborn Errors Working Party of the European Group for Blood and Marrow Transplantation

    Blood, 22 March 2012, Volume 119, Number 12

  3. Outcomes after related and unrelated umbilical cord blood transplantation for hereditary bone marrow failure syndromes other than Fanconi anemia

    Renata Bizzetto, Carmen Bonfim, Vanderson Rocha, Gérard Socié, Franco Locatelli, KaWah Chan, Oscar Ramirez, Joel Stein, Samir Nabhan, Eliana Miranda, Jakob Passweg, Carmino Antonio de Souza CA,
    Eliane Gluckman on behalf of Eurocord and SAA-WP from EBMT

    Haematologica 2011; 96(1)

  4. Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT

    Andrée-Laure Herr, Nabil Kabbara, Carmem M. S. Bonfim, Pierre Teira, Franco Locatelli, Karin Tiedemann, Arjan Lankester, Jean-Pierre Jouet, Chiara Messina, Yves Bertrand, Cristina Díaz de Heredia, Christina Peters, Wagnara Chaves, Samir K. Nabhan, Irina Ionescu, Eliane Gluckman, and Vanderson Rocha

    Blood, 16 September 2010  Volume 116, Number 11

Ipossia e paralisi cerebrale infantile

  1. Rescuing the neonatal brain from hypoxic injury with autologous cord blood

    Y Liao, M Cotten, S Tan, J Kurtzberg and MS Cairo

    Bone Marrow Transplantation (2013) 48, 890–900;
    doi:10.1038/bmt.2012.169

  2. Feasibility of Autologous Cord Blood Cells for Infants with Hypoxic-Ischemic Encephalopathy

    C. Michael Cotten, Amy P. Murtha, Ronald N. Goldberg, Chad A. Grotegut, P. Brian Smith, Ricki F. Goldstein, Kimberley A. Fisher, Kathryn E. Gustafson, Barbara Waters-Pick, Geeta K. Swamy, Benjamin Rattray, Siddhartha Tan, and Joanne Kurtzberg

    J. Pediatr 2014

  3. Stem cell therapy to protect and repair the developing brain: are view of mechanisms of action of cord blood and amnion epithelial derived cells

    Margie Castillo-Melendez, Tamara Yawno, Graham Jenkin and Suzanne L. Miller

    Frontiers in Neurosciences 4 October 2013
    doi: 10.3389/fnins.2013.00194

Malattie neurologiche

  1. Neurodevelopmental outcomes of umbilical cord blood transplantation in metachromatic leukodystrophy

    Martin HR, Poe MD, Provenzale JM, Kurtzberg J, Mendizabal A, Escolar ML

    Biol Blood Marrow Transplant. 2013 Apr;19(4):616-24
    doi: 10.1016/j.bbmt.2013.01.010

Danni cerebrali da trauma

  1. Human umbilical cord blood‑derived mesenchymal stem cell transplantation for the treatment of spinal cord injury

    Bingzhou Cui, En Li, Bo Yang and Bo Wang

    Experimental and Therapeutic Medicine 7: 1233-1236, 2014
    Doi: 10.3892/etm.2014.1608

  2. Combination Therapy of Human Umbilical Cord Blood Cells and Granulocyte Colony Stimulating Factor Reduces Histopathological and Motor Impairments in an Experimental Model of Chronic Traumatic Brain Injury

    Sandra A. Acosta, Naoki Tajiri, Kazutaka Shinozuka, Hiroto Ishikawa, Paul R. Sanberg, Juan Sanchez-Ramos, Shijie Song, Yuji Kaneko, Cesar V. Borlongan

    Plos One, March 2014, Volume 9

Patologia della retina

  1. Vascular Progenitors From Cord Blood-Derived Induced Pluripotent Stem Cells Possess Augmented Capacity for Regenerating Ischemic Retinal Vasculature

    Tea Soon Park, Imran Bhutto, Ludovic Zimmerlin, Jeffrey S. Huo, Pratik Nagaria, Diana Miller, Abdul Jalil Rufaihah, Connie Talbot, Jack Aguilar, Rhonda Grebe, Carol Merges, Renee Reijo-Pera, Ricardo A. Feldman, Feyruz Rassool, John Cooke, Gerard Lutty and Elias T. Zambidis

    Circulation. 2014;129:359-372; originally published online October 25, 2013;
    Doi: 10.1161/CIRCULATIONAHA.113.003000

Terapia genica

  1. Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

    Marina Cavazzana-Calvo, Emmanuel Payen, Olivier Negre, Gary Wang, Kathleen Hehir, Floriane Fusil, Julian Down, Maria Denaro, Troy Brad7, Karen Westerman, Resy Cavallesco, Beatrix Gillet-Legrand, Laure Caccavelli, Riccardo Sgarra, Leila Maouche-Chrétien, Françoise Bernaudin, Robert Girot, Ronald Dorazio, Geert-Jan Mulder, Axel Polack, Arthur Bank, Jean Soulier, Jérôme Larghero, Nabil Kabbara, Bruno Dalle, Bernard Gourmel, Gérard Socie, Stany Chrétien, Nathalie Cartier, Patrick Aubourg, Alain Fischer, Kenneth Cornetta, Frédéric Galacteros, Yves Beuzard, Eliane Gluckman, Frederick Bushman, Salima Hacein-Bey-Abina, and Philippe Leboulch

    Nature. 2010 September 16; 467(7313): 318–322.
    doi:10.1038/nature09328

  2. Umbilical Cord Blood Transplantation for Children with Thalassemia and Sickle Cell Disease

    Annalisa Ruggeri, Mary Eapen, Andromachi Scaravadou, Mitchell S. Cairo, Monica Bhatia, Joanne Kurtzberg, John R. Wingard, Anders Fasth, Luca Lo Nigro, Mouhab Ayas, Duncan Purtill, Karim Boudjedir, Wagnara Chaves, Mark C. Walters, John Wagner, Eliane Gluckman, and Vanderson Rocha for the Eurocord Registry, the Center for International Blood and Marrow Transplant Research, and the New York Blood Center

    Biol Blood Marrow Transplant. 2011 September ; 17(9): 1375–1382.
    doi:10.1016/j.bbmt.2011.01.012.

  3. T lymphocytes with a normal ADA gene accumulate after transplantation of transduced autologous umbilical cord blood CD34+ cells in ADA-deficient SCID neonates

    Donald B. Kohn, Michael S. Hershfield, Denise Carbonaro, Ann Shigeoka, Judith Brooks, E. Monika Smogorzewska, Lora W. Barsky, Raymond Chan, Felix Burotto, Geralyn Annett, Jan A. Nolta, Gay Crooks, Neena Kapoor, Melissa Elder, Diane Wara, Thomas Bowen, Edward Madsen, Floyd F. Snyder, John Bastian, Linda Muul, R. Michael Blaese, Kenneth Weinberg, and Robertson Parkman

    Nat Med. 1998 July ; 4(7): 775–780

Altre applicazioni

  1. An Expanded Population of CD34+ Cells from Frozen Banked Umbilical Cord Blood Demonstrate Tissue Repair Mechanisms of Mesenchymal Stromal Cells and Circulating Angiogenic Cells in an Ischemic Hind Limb Model

    Jennifer Whiteley, Ryszard Bielecki, Mira Li, Shawn Chua, Michael R.Ward, Nobuko Yamanaka, Duncan J. Stewart, Robert F. Casper, Ian M. Rogers

    Stem Cell Rev and Rep
    Doi 10.1007/s12015-014-9496-1

  2. Reversal of type 1 diabetes via islet beta cell regeneration following immune modulation by cord blood-derived multipotent stem cells

    Yong Zhao, Zhaoshun Jiang, Tingbao Zhao, Mingliang Ye, Chengjin Hu, Zhaohui Yin, Heng Li, Ye Zhang,
    Yalin Diao, Yunxiang Li, Yingjian Chen, Xiaoming Sun, Mary Beth Fisk, Randal Skidgel, Mark Holterman,
    Bellur Prabhakar and Theodore Mazzone

    BMC Medicine 2012, 10:3

  3. Hematopoietic cell transplantation with cord blood for cure of HIV infections

    Petz LD, Redei I, Bryson Y, Regan D, Kurtzberg J, Shpall E, Gutman J, Querol S, Clark P, Tonai R, Santos S, Bravo A, Spellman S, Gragert L, Rossi J, Li S, Li H, Senitzer D, Zaia J, Rosenthal J, Forman S, Chow R.

    Biol Blood Marrow Transplant. 2013 Mar;19(3):393-7.
    Doi: 10.1016/j.bbmt.2012.10.017.

  4. Treatment of recalcitrant ulcers with allogeneic platelet gel from pooled platelets in aged hypomobile patients

    N. Greppi, L. Mazzucco, G. Galetti, F. Bona, E. Petrillo, C. Smacchia, E. Raspollini, P. Cossovich, R. Caprioli, P. Borzini, P. Rebulla, M. Marconi

    Biologicals 39 (2011) 73 e 80